The complex relationship between space, pedagogy and technology is a continuously evolving concept. It is important for those in teaching to determine the effectiveness of these relationships for the betterment of education, especially when addressing the needs of 21st Century learners who attend higher learning institutions. Evaluation of these concepts is based around three key areas: pedagogies designed to accommodate a more active and engaging learning and teaching ecosystem; interactive physical learning spaces (ILS), which break through traditional lecture set-ups; and technology relevant to the 21st Century. The Post-Occupancy Evaluation (POE) is a tool developed by Steelcase Education to evaluate the success of students in relation to space. In the past, this analysis has only been used to measure engagement of students. To be more conclusive, the POE was analyzed and used it to measure the relationship between the three different elements. In collaboration with Steelcase Education, the experiment was implemented at Ball State University, a mid-sized institution located in the Midwestern United States, with faculty and students. The experiment examined the relationship between space, pedagogy and technology versus achievement in the course.